Direct transformation of arylpropynes to acrylamides via a three-step tandem reaction.

A green synthesis of functionalized thiazol-2(3H)-imine via a three-component tandem reaction in ionic liquid media

In this research, an efficient synthesis toward 2-(2-((4-Methoxybenzoyl)imino)-4-(4-methoxyphenyl)thiazol-3(2H)-yl)-2-phenylacetic acid via a three-component tandem reaction using aroylisothiocyanate, phenyl glycine, and 4-methoxyphenacyl bromide in an ionic liquid (IL) has been described. 1-Methyl-3-pentylimidazolium bromide (IL) has been employed as a recyclable green solvent. The work-up pro...

One-pot Synthesis of Pyrono [2,3] Quinoline via the Tandem Cyclization of Algar-Flyn-Oyamanda Reactions

A new and imaginative technique for the synthesis of substituted pyranoquinoline via Algar Flyn Oyamanda oxidation cyclization approach has been achieved by hydrogen peroxide and sodium hydroxide catalyzed of quinoline chalcone with intramolecular cyclization to formed pyranoquinoline. In this reaction, two new C-C bonds were formed in a one step with high atom economy. The possible reaction pa...

Silver-catalyzed oxidative coupling/cyclization of acrylamides with 1,3-dicarbonyl compounds.

An efficient silver-catalyzed oxidative cyclization of acrylamides with 1,3-dicarbonyl compounds is described. It proceeds through a tandem radical addition/cyclization process, in which two new C-C bonds were formed. Furthermore, the same concept can also be extended to the reaction of easily available ketones and acrylamides.

Thermodynamics and Kinetics of Spiro-Heterocycle Formation Mechanism: Computational Study

Reaction mechanism among indoline-2,3-dione, pyrrolidine-2-carboxylic acid and (Z)-2-(1-(2-hydroxynaphthalen-1-yl)ethylidene)hydroxycarboxamide to form 1’-((((aminooxy)carbonyl)amino)methyl)-2’-(1-hydroxynaphthalen-2-yl)-2’-methyl-1’,2’,5’,6’,7’,7a’-hexahydrospiro[indoline-3,3’-pyrrolo[1,2-a]imidazole-2-one was investigated using density functional theory (DFT) at B3LYP basis theory. The three-...

Synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions via Phosphorus pentoxide supported on alumina (P2O5/Al2O3) catalyzed tandem reaction of Aldehyde with dimedone